Which two markers are reported as positive for a urothelial lesion described with CD10 and EMA positivity?

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Multiple Choice

Which two markers are reported as positive for a urothelial lesion described with CD10 and EMA positivity?

Explanation:
This question hinges on recognizing the immunohistochemical profile described for the lesion. If the urothelial lesion is reported as positive for CD10 and epithelial membrane antigen (EMA), those two markers are the ones described as positive. EMA marks epithelial cells and is commonly positive in carcinomas, while CD10 can be expressed in some urothelial tumors. The other marker pairs point to different cell lineages—CD3 and CD20 for lymphoid cells, S100 and HMB45 for melanocytic lesions, and CK7/CK20 are cytokeratins that aren’t specified as positives in this description. So the two markers reported as positive are EMA and CD10.

This question hinges on recognizing the immunohistochemical profile described for the lesion. If the urothelial lesion is reported as positive for CD10 and epithelial membrane antigen (EMA), those two markers are the ones described as positive. EMA marks epithelial cells and is commonly positive in carcinomas, while CD10 can be expressed in some urothelial tumors. The other marker pairs point to different cell lineages—CD3 and CD20 for lymphoid cells, S100 and HMB45 for melanocytic lesions, and CK7/CK20 are cytokeratins that aren’t specified as positives in this description. So the two markers reported as positive are EMA and CD10.

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