Which subgroup has the highest grade?

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Multiple Choice

Which subgroup has the highest grade?

Explanation:
Grade reflects how abnormal the cancer cells look and how quickly they divide. Basal-like breast cancers are typically triple-negative and show poor differentiation with high mitotic activity, which means they’re most often high-grade. In contrast, luminal A cancers are usually well differentiated and low-grade, while luminal B cancers are higher grade than A but not necessarily the highest. HER2-enriched tumors can be high-grade, but basal tumors most consistently exhibit the features that lead to the highest grade.

Grade reflects how abnormal the cancer cells look and how quickly they divide. Basal-like breast cancers are typically triple-negative and show poor differentiation with high mitotic activity, which means they’re most often high-grade. In contrast, luminal A cancers are usually well differentiated and low-grade, while luminal B cancers are higher grade than A but not necessarily the highest. HER2-enriched tumors can be high-grade, but basal tumors most consistently exhibit the features that lead to the highest grade.

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