Which statement correctly matches BRCA1 and BRCA2 tumor subtypes?

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Multiple Choice

Which statement correctly matches BRCA1 and BRCA2 tumor subtypes?

Explanation:
Mutations in BRCA1 and BRCA2 tend to steer breast cancers toward different molecular patterns. BRCA1-associated tumors most often show a basal-like profile and lack hormone receptors, which classifies them as triple-negative breast cancers. This basal/TNBC phenotype reflects the gene-expression patterns typically seen when BRCA1 function is lost. BRCA2-associated tumors, in contrast, more commonly fall into the luminal category, especially luminal B. These cancers are usually estrogen receptor–positive and tend to have higher proliferation than luminal A tumors, fitting the luminal B subtype. So the statement pairing BRCA1 with basal/TNBC and BRCA2 with luminal B aligns with the common clinical-genetic patterns observed. There can be exceptions, but this is the general relationship.

Mutations in BRCA1 and BRCA2 tend to steer breast cancers toward different molecular patterns. BRCA1-associated tumors most often show a basal-like profile and lack hormone receptors, which classifies them as triple-negative breast cancers. This basal/TNBC phenotype reflects the gene-expression patterns typically seen when BRCA1 function is lost.

BRCA2-associated tumors, in contrast, more commonly fall into the luminal category, especially luminal B. These cancers are usually estrogen receptor–positive and tend to have higher proliferation than luminal A tumors, fitting the luminal B subtype.

So the statement pairing BRCA1 with basal/TNBC and BRCA2 with luminal B aligns with the common clinical-genetic patterns observed. There can be exceptions, but this is the general relationship.

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