Which staining result is described as TTf-1, PAX8?

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Multiple Choice

Which staining result is described as TTf-1, PAX8?

Explanation:
Positivity for both TTF-1 and PAX8 indicates thyroid-origin immunophenotype. TTF-1 is a nuclear factor seen in thyroid (and lung) epithelium, while PAX8 marks thyroid, kidney, and Müllerian-derived tissues. When a tumor shows staining for both, it strongly supports thyroid lineage, since thyroid tissue commonly expresses both markers. This helps distinguish it from other origins: for example, CDX2 points to intestinal origin, Melan-A positivity suggests melanoma, and c-kit with DOG-1 indicates a GIST. So the staining pattern described as TTF-1 and PAX8 positive best fits a thyroid-derived profile.

Positivity for both TTF-1 and PAX8 indicates thyroid-origin immunophenotype. TTF-1 is a nuclear factor seen in thyroid (and lung) epithelium, while PAX8 marks thyroid, kidney, and Müllerian-derived tissues. When a tumor shows staining for both, it strongly supports thyroid lineage, since thyroid tissue commonly expresses both markers. This helps distinguish it from other origins: for example, CDX2 points to intestinal origin, Melan-A positivity suggests melanoma, and c-kit with DOG-1 indicates a GIST. So the staining pattern described as TTF-1 and PAX8 positive best fits a thyroid-derived profile.

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