Which stain does NOT stain myoepithelial cells?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

Which stain does NOT stain myoepithelial cells?

Explanation:
The key idea is how immunohistochemical markers differentiate myoepithelial cells from luminal epithelial cells. Myoepithelial cells express markers that reflect their contractile, basal-like nature: p63 or p40 mark nuclei of basal/myoepithelial cells, while calponin and smooth muscle actin (SMA) highlight their cytoplasmic contractile components. In contrast, CAM 5.2 targets low molecular weight cytokeratins associated with luminal epithelial cells, not the contractile myoepithelial layer. So CAM 5.2 will typically label the epithelial component but not the myoepithelial cells, making it the stain that does not stain myoepithelial cells.

The key idea is how immunohistochemical markers differentiate myoepithelial cells from luminal epithelial cells. Myoepithelial cells express markers that reflect their contractile, basal-like nature: p63 or p40 mark nuclei of basal/myoepithelial cells, while calponin and smooth muscle actin (SMA) highlight their cytoplasmic contractile components. In contrast, CAM 5.2 targets low molecular weight cytokeratins associated with luminal epithelial cells, not the contractile myoepithelial layer. So CAM 5.2 will typically label the epithelial component but not the myoepithelial cells, making it the stain that does not stain myoepithelial cells.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy