Which pattern shows GATA3 positivity with potential variable ER/PR/HER2?

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Multiple Choice

Which pattern shows GATA3 positivity with potential variable ER/PR/HER2?

Explanation:
GATA3 is used in immunohistochemistry to point to breast or urothelial origin. In breast cancer, ER, PR, and HER2 status can vary widely from tumor to tumor, so you can see GATA3 positivity with negative, positive, or mixed ER/PR/HER2 results. This pattern—GATA3 positive with ER/PR/HER2 either negative or positive—fits breast carcinoma where receptor status is not fixed. The other patterns lean toward a different lineage (for example, Napsin A and TTF-1 positivity are typical of lung adenocarcinoma, not breast), so they don’t match the described combination as well.

GATA3 is used in immunohistochemistry to point to breast or urothelial origin. In breast cancer, ER, PR, and HER2 status can vary widely from tumor to tumor, so you can see GATA3 positivity with negative, positive, or mixed ER/PR/HER2 results. This pattern—GATA3 positive with ER/PR/HER2 either negative or positive—fits breast carcinoma where receptor status is not fixed. The other patterns lean toward a different lineage (for example, Napsin A and TTF-1 positivity are typical of lung adenocarcinoma, not breast), so they don’t match the described combination as well.

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