Which panel would be most informative to confirm breast origin if analyzing mediastinal lymph node metastasis?

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Multiple Choice

Which panel would be most informative to confirm breast origin if analyzing mediastinal lymph node metastasis?

Explanation:
GATA3 is a marker commonly seen in breast carcinomas, and the hormone receptors (ER/PR) and HER2 status are characteristic features of breast cancers. When a mediastinal lymph node metastasis is being profiled, a panel that shows GATA3 positivity together with breast-specific receptor status provides the strongest evidence for breast origin. Lung cancers typically express Napsin A and TTF-1, so panels with those markers point toward pulmonary origin. Therefore, the combination of GATA3 positivity with ER/PR/HER2 status is the most informative for confirming breast origin in this setting.

GATA3 is a marker commonly seen in breast carcinomas, and the hormone receptors (ER/PR) and HER2 status are characteristic features of breast cancers. When a mediastinal lymph node metastasis is being profiled, a panel that shows GATA3 positivity together with breast-specific receptor status provides the strongest evidence for breast origin. Lung cancers typically express Napsin A and TTF-1, so panels with those markers point toward pulmonary origin. Therefore, the combination of GATA3 positivity with ER/PR/HER2 status is the most informative for confirming breast origin in this setting.

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