Which panel is most likely to include SALL4 as a marker?

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Multiple Choice

Which panel is most likely to include SALL4 as a marker?

Explanation:
SALL4 is a nuclear transcription factor that marks germ cell lineage and is highly sensitive for germ cell tumors. In pathology, this marker helps confirm a tumor’s germ cell origin because it is typically positive in ovarian germ cell tumors (such as yolk sac tumors and other germ cell components) but not in non-germ cell tumors. Therefore, a panel representing primary ovarian germ cell tumors would be the one most likely to include SALL4, whereas panels for ovarian stromal sarcomas, adrenal cortical tissue, or parathyroid carcinoma would not usually rely on SALL4.

SALL4 is a nuclear transcription factor that marks germ cell lineage and is highly sensitive for germ cell tumors. In pathology, this marker helps confirm a tumor’s germ cell origin because it is typically positive in ovarian germ cell tumors (such as yolk sac tumors and other germ cell components) but not in non-germ cell tumors. Therefore, a panel representing primary ovarian germ cell tumors would be the one most likely to include SALL4, whereas panels for ovarian stromal sarcomas, adrenal cortical tissue, or parathyroid carcinoma would not usually rely on SALL4.

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