Which of the following is NOT included in the IHC panel for primary ovarian carcinoma?

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Multiple Choice

Which of the following is NOT included in the IHC panel for primary ovarian carcinoma?

Explanation:
In immunohistochemistry, the goal is to detect specific proteins in tissue to help classify the tumor and its origin. WT1 is a classic marker that supports serous ovarian carcinoma, and HER2 can be evaluated in some ovarian cancers for targeted therapy considerations. CA-125 is tied to ovarian cancer as a serum marker and can be detected in tissue in some settings, though its primary role is not as an IHC workhorse. BRCA1, by contrast, is a gene whose status is determined by genetic/molecular testing (sequencing, deletion/duplication analysis) rather than an immunohistochemical stain. It informs hereditary risk and PARP-inhibitor therapy, not the routine histologic panel used to identify ovarian carcinoma. So BRCA1 is not included in the IHC panel.

In immunohistochemistry, the goal is to detect specific proteins in tissue to help classify the tumor and its origin. WT1 is a classic marker that supports serous ovarian carcinoma, and HER2 can be evaluated in some ovarian cancers for targeted therapy considerations. CA-125 is tied to ovarian cancer as a serum marker and can be detected in tissue in some settings, though its primary role is not as an IHC workhorse. BRCA1, by contrast, is a gene whose status is determined by genetic/molecular testing (sequencing, deletion/duplication analysis) rather than an immunohistochemical stain. It informs hereditary risk and PARP-inhibitor therapy, not the routine histologic panel used to identify ovarian carcinoma. So BRCA1 is not included in the IHC panel.

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