Which mutation is associated with breast carcinomas?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

Which mutation is associated with breast carcinomas?

Explanation:
Mutations in BRCA1 and BRCA2 are linked to breast carcinomas because they encode tumor suppressor proteins that repair DNA damage, specifically double-strand breaks, through homologous recombination. When these genes are mutated, repair is faulty, leading to genomic instability and a higher risk of cancer development in breast tissue. BRCA1/2 mutations are the best-known inherited risk factors for breast cancer and explain much of the familial clustering of the disease. The other genes listed are more commonly associated with different cancers or signaling pathways (KRAS and BRAF with various solid tumors, EGFR in several cancers), not with a primary predisposition to breast cancer.

Mutations in BRCA1 and BRCA2 are linked to breast carcinomas because they encode tumor suppressor proteins that repair DNA damage, specifically double-strand breaks, through homologous recombination. When these genes are mutated, repair is faulty, leading to genomic instability and a higher risk of cancer development in breast tissue. BRCA1/2 mutations are the best-known inherited risk factors for breast cancer and explain much of the familial clustering of the disease. The other genes listed are more commonly associated with different cancers or signaling pathways (KRAS and BRAF with various solid tumors, EGFR in several cancers), not with a primary predisposition to breast cancer.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy