Which marker is part of the IHC panel for primary colonic adenocarcinoma?

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Multiple Choice

Which marker is part of the IHC panel for primary colonic adenocarcinoma?

Explanation:
CDX2 is a nuclear transcription factor that marks intestinal differentiation. In colorectal adenocarcinoma, you typically see strong nuclear CDX2 expression, which helps confirm a primary colonic/intestinal origin or distinguish metastases from non-intestinal sites. The other markers point to different origins: CA-125 and PAX8 suggest ovarian or Müllerian lineage, while CK7 is a general cytokeratin with less specificity for colorectal origin (colorectal cancers are often CK20 positive and CK7 negative). Because CDX2 directly indicates intestinal differentiation, it’s the most informative marker for identifying primary colonic adenocarcinoma in an IHC panel.

CDX2 is a nuclear transcription factor that marks intestinal differentiation. In colorectal adenocarcinoma, you typically see strong nuclear CDX2 expression, which helps confirm a primary colonic/intestinal origin or distinguish metastases from non-intestinal sites. The other markers point to different origins: CA-125 and PAX8 suggest ovarian or Müllerian lineage, while CK7 is a general cytokeratin with less specificity for colorectal origin (colorectal cancers are often CK20 positive and CK7 negative). Because CDX2 directly indicates intestinal differentiation, it’s the most informative marker for identifying primary colonic adenocarcinoma in an IHC panel.

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