Which marker is NOT typically positive in GIST?

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Multiple Choice

Which marker is NOT typically positive in GIST?

Explanation:
In GIST, the immunohistochemical profile is dominated by markers tied to interstitial cells of Cajal. The most characteristic positives are c-KIT (CD117) and DOG-1, with CD34 also commonly expressed. S100, however, is a neural crest marker more typical of tumors like schwannomas or melanocytic lesions and is not expected to be positive in GIST. While rare cases might show weak S100, it is not a typical finding, making S100 the best choice for a marker that is not usually positive in GIST.

In GIST, the immunohistochemical profile is dominated by markers tied to interstitial cells of Cajal. The most characteristic positives are c-KIT (CD117) and DOG-1, with CD34 also commonly expressed. S100, however, is a neural crest marker more typical of tumors like schwannomas or melanocytic lesions and is not expected to be positive in GIST. While rare cases might show weak S100, it is not a typical finding, making S100 the best choice for a marker that is not usually positive in GIST.

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