Which marker is NOT typically included in the IHC panel for primary adrenal cortical tissue?

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Multiple Choice

Which marker is NOT typically included in the IHC panel for primary adrenal cortical tissue?

Explanation:
Immunohistochemical panels for identifying adrenal cortical tissue rely on markers that reflect adrenal lineage. SF-1 is a transcription factor essential to adrenal development and function, so staining for SF-1 is a strong indicator of adrenocortical origin. Melan-A is also commonly expressed in adrenal cortical cells, helping support the adrenal identity in tissue samples. Inhibin can be expressed in adrenal cortex as well and serves as an additional supportive marker. PTH, however, marks parathyroid tissue rather than adrenal cortex; it wouldn’t help identify adrenocortical tissue, so it isn’t included in the standard adrenal cortical IHC panel.

Immunohistochemical panels for identifying adrenal cortical tissue rely on markers that reflect adrenal lineage. SF-1 is a transcription factor essential to adrenal development and function, so staining for SF-1 is a strong indicator of adrenocortical origin. Melan-A is also commonly expressed in adrenal cortical cells, helping support the adrenal identity in tissue samples. Inhibin can be expressed in adrenal cortex as well and serves as an additional supportive marker. PTH, however, marks parathyroid tissue rather than adrenal cortex; it wouldn’t help identify adrenocortical tissue, so it isn’t included in the standard adrenal cortical IHC panel.

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