Which marker is NOT part of the IHC panel for primary medullary thyroid carcinoma?

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Multiple Choice

Which marker is NOT part of the IHC panel for primary medullary thyroid carcinoma?

Explanation:
Medullary thyroid carcinoma originates from parafollicular C cells, so its immunohistochemical profile centers on markers of C‑cell and neuroendocrine differentiation. Calcitonin is the hallmark positive marker for C‑cell origin, and neuroendocrine markers like Chromogranin A and Synaptophysin are commonly expressed. Thyroglobulin, on the other hand, is produced by thyroid follicular cells, not C cells, so MTC typically does not express thyroglobulin. Because thyroglobulin would point to follicular-derived thyroid carcinomas rather than MTC, it is not part of the standard IHC panel used to confirm primary medullary thyroid carcinoma.

Medullary thyroid carcinoma originates from parafollicular C cells, so its immunohistochemical profile centers on markers of C‑cell and neuroendocrine differentiation. Calcitonin is the hallmark positive marker for C‑cell origin, and neuroendocrine markers like Chromogranin A and Synaptophysin are commonly expressed. Thyroglobulin, on the other hand, is produced by thyroid follicular cells, not C cells, so MTC typically does not express thyroglobulin. Because thyroglobulin would point to follicular-derived thyroid carcinomas rather than MTC, it is not part of the standard IHC panel used to confirm primary medullary thyroid carcinoma.

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