Which marker is NOT included in the hepatocellular carcinoma IHC panel?

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Multiple Choice

Which marker is NOT included in the hepatocellular carcinoma IHC panel?

Explanation:
Immunohistochemical panels for hepatocellular carcinoma rely on markers that reflect hepatocyte differentiation and tumor behavior. HepPar1 is a marker of hepatocyte lineage and typically stains hepatocellular carcinoma. GPC3 is an oncofetal protein often positive in hepatocellular carcinoma and helps support the diagnosis. AFP can be expressed in hepatocellular carcinoma and is sometimes included in the panel to bolster detection. Cytokeratin 7, however, marks biliary epithelium and is more characteristic of cholangiocarcinoma or biliary-type adenocarcinomas; hepatocellular carcinomas are usually CK7-negative, so CK7 is not part of the standard hepatocellular carcinoma IHC panel.

Immunohistochemical panels for hepatocellular carcinoma rely on markers that reflect hepatocyte differentiation and tumor behavior. HepPar1 is a marker of hepatocyte lineage and typically stains hepatocellular carcinoma. GPC3 is an oncofetal protein often positive in hepatocellular carcinoma and helps support the diagnosis. AFP can be expressed in hepatocellular carcinoma and is sometimes included in the panel to bolster detection. Cytokeratin 7, however, marks biliary epithelium and is more characteristic of cholangiocarcinoma or biliary-type adenocarcinomas; hepatocellular carcinomas are usually CK7-negative, so CK7 is not part of the standard hepatocellular carcinoma IHC panel.

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