Which marker is NOT in the IHC panel for primary papillary thyroid carcinoma (PTC)?

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Multiple Choice

Which marker is NOT in the IHC panel for primary papillary thyroid carcinoma (PTC)?

Explanation:
Immunohistochemistry for papillary thyroid carcinoma relies on markers of follicular-cell origin. Markers like Thyroid Transcription Factor-1 (TTF-1) support thyroid origin; Cytokeratin 19 (CK19) is commonly overexpressed in papillary tumors; and HBME-1 tends to be positive in malignant thyroid lesions, helping distinguish PTC from benign nodules. Calcitonin, however, is produced by parafollicular C cells and is a hallmark of medullary thyroid carcinoma, not papillary carcinoma. Its presence would point away from PTC and toward medullary carcinoma, so Calcitonin is not part of the typical IHC panel used to diagnose primary papillary thyroid carcinoma.

Immunohistochemistry for papillary thyroid carcinoma relies on markers of follicular-cell origin. Markers like Thyroid Transcription Factor-1 (TTF-1) support thyroid origin; Cytokeratin 19 (CK19) is commonly overexpressed in papillary tumors; and HBME-1 tends to be positive in malignant thyroid lesions, helping distinguish PTC from benign nodules. Calcitonin, however, is produced by parafollicular C cells and is a hallmark of medullary thyroid carcinoma, not papillary carcinoma. Its presence would point away from PTC and toward medullary carcinoma, so Calcitonin is not part of the typical IHC panel used to diagnose primary papillary thyroid carcinoma.

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