Which marker is included in the IHC panel for primary squamous cell carcinoma of the cervix?

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Multiple Choice

Which marker is included in the IHC panel for primary squamous cell carcinoma of the cervix?

Explanation:
The marker most useful here is p16. In cervical squamous cell carcinomas, infection with high‑risk HPV drives overexpression of p16 due to the HPV E7 protein inactivating the Rb pathway. This makes p16 a reliable surrogate marker in immunohistochemistry to support HPV-related cervical squamous neoplasia. In practice, a strong, diffuse p16 staining pattern is typical of HPV-associated cervical squamous lesions, helping confirm the diagnosis. The other markers aren’t relevant for this context: PSMA is associated with prostate tissue, GFAP with glial cells, and MUC2 with certain mucinous or signet-ring/type adenocarcinomas.

The marker most useful here is p16. In cervical squamous cell carcinomas, infection with high‑risk HPV drives overexpression of p16 due to the HPV E7 protein inactivating the Rb pathway. This makes p16 a reliable surrogate marker in immunohistochemistry to support HPV-related cervical squamous neoplasia. In practice, a strong, diffuse p16 staining pattern is typical of HPV-associated cervical squamous lesions, helping confirm the diagnosis.

The other markers aren’t relevant for this context: PSMA is associated with prostate tissue, GFAP with glial cells, and MUC2 with certain mucinous or signet-ring/type adenocarcinomas.

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