Which marker is included in the IHC panel for primary HGUC?

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Multiple Choice

Which marker is included in the IHC panel for primary HGUC?

Explanation:
GATA3 is included because it highlights urothelial differentiation and is positive in the vast majority of primary urothelial carcinomas, including high-grade cases. This makes it a reliable marker to confirm urothelial origin when diagnosing HGUC. PAX8 would suggest a renal or Müllerian source rather than urothelial, CAIX points to clear cell RCC, and HER2 is not a standard diagnostic marker for HGUC. So GATA3 best fits the panel for confirming primary HGUC.

GATA3 is included because it highlights urothelial differentiation and is positive in the vast majority of primary urothelial carcinomas, including high-grade cases. This makes it a reliable marker to confirm urothelial origin when diagnosing HGUC. PAX8 would suggest a renal or Müllerian source rather than urothelial, CAIX points to clear cell RCC, and HER2 is not a standard diagnostic marker for HGUC. So GATA3 best fits the panel for confirming primary HGUC.

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