Which marker is included in the IHC panel for primary prostatic adenocarcinoma?

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Multiple Choice

Which marker is included in the IHC panel for primary prostatic adenocarcinoma?

Explanation:
In identifying the tissue of origin for a carcinoma, immunohistochemical markers that are characteristic of a specific organ are used. Prostate tissue produces PSA, so detecting PSA by IHC in a tumor supports a prostatic origin and helps confirm that a prostatic adenocarcinoma is present. PSA is a classic and widely validated marker that laboratories routinely include in panels to verify prostatic differentiation, often alongside other markers like NKX3.1. While other markers exist and can be informative, PSA’s long-standing use and proven specificity make it a standard choice for confirming primary prostatic adenocarcinoma.

In identifying the tissue of origin for a carcinoma, immunohistochemical markers that are characteristic of a specific organ are used. Prostate tissue produces PSA, so detecting PSA by IHC in a tumor supports a prostatic origin and helps confirm that a prostatic adenocarcinoma is present. PSA is a classic and widely validated marker that laboratories routinely include in panels to verify prostatic differentiation, often alongside other markers like NKX3.1. While other markers exist and can be informative, PSA’s long-standing use and proven specificity make it a standard choice for confirming primary prostatic adenocarcinoma.

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