Which marker is included in the IHC panel for primary EM adenocarcinoma?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

Which marker is included in the IHC panel for primary EM adenocarcinoma?

Explanation:
PAX8 is used because it marks tumors of Müllerian origin, including the endometrium. It’s a nuclear transcription factor that’s typically positive in endometrial adenocarcinomas, helping confirm the tumor arises from the uterus rather than being a metastasis from another site. While CK20 and CD10 can provide clues about other origins (CK20 often points to colorectal tumors, CD10 to endometrial stromal lesions), and HER2 can be variably expressed in some subtypes, PAX8 specifically supports endometrial origin and is the most informative marker for this purpose.

PAX8 is used because it marks tumors of Müllerian origin, including the endometrium. It’s a nuclear transcription factor that’s typically positive in endometrial adenocarcinomas, helping confirm the tumor arises from the uterus rather than being a metastasis from another site. While CK20 and CD10 can provide clues about other origins (CK20 often points to colorectal tumors, CD10 to endometrial stromal lesions), and HER2 can be variably expressed in some subtypes, PAX8 specifically supports endometrial origin and is the most informative marker for this purpose.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy