Which marker is included in the IHC panel for astrocytomas?

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Multiple Choice

Which marker is included in the IHC panel for astrocytomas?

Explanation:
GFAP is a glial marker, specifically an intermediate filament protein expressed in astrocytes. In astrocytomas, staining for GFAP helps confirm glial differentiation and supports the diagnosis by highlighting tumor cells of astrocytic origin. The other markers point to non-glial lineages: CD10 is seen in various carcinomas and hematologic contexts, PAX8 marks renal, thyroid, and Müllerian tumors, and CAIX is most associated with hypoxic/clear cell renal cell carcininoma. Because GFAP directly identifies astrocytic lineage, it’s the appropriate marker to include in an IHC panel for astrocytomas.

GFAP is a glial marker, specifically an intermediate filament protein expressed in astrocytes. In astrocytomas, staining for GFAP helps confirm glial differentiation and supports the diagnosis by highlighting tumor cells of astrocytic origin. The other markers point to non-glial lineages: CD10 is seen in various carcinomas and hematologic contexts, PAX8 marks renal, thyroid, and Müllerian tumors, and CAIX is most associated with hypoxic/clear cell renal cell carcininoma. Because GFAP directly identifies astrocytic lineage, it’s the appropriate marker to include in an IHC panel for astrocytomas.

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