Which marker is commonly positive in urothelial carcinoma?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

Which marker is commonly positive in urothelial carcinoma?

Explanation:
Immunohistochemical confirmation of urothelial differentiation relies on uroplakins, proteins expressed by the surface umbrella cells of the urothelium. Uroplakin II is commonly positive in urothelial carcinoma, reflecting the tumor’s origin from urothelial cells and helping distinguish it from metastases of non-urothelial cancers. While CK7 can be positive and CK20 may be variably positive in urothelial tumors, these cytokeratins are less specific and can be seen in other carcinomas. S100 is not characteristic of urothelial carcinoma and is typically associated with melanocytic or neural tumors. Thus, Uroplakin II stands out as a reliable marker indicating urothelial lineage.

Immunohistochemical confirmation of urothelial differentiation relies on uroplakins, proteins expressed by the surface umbrella cells of the urothelium. Uroplakin II is commonly positive in urothelial carcinoma, reflecting the tumor’s origin from urothelial cells and helping distinguish it from metastases of non-urothelial cancers. While CK7 can be positive and CK20 may be variably positive in urothelial tumors, these cytokeratins are less specific and can be seen in other carcinomas. S100 is not characteristic of urothelial carcinoma and is typically associated with melanocytic or neural tumors. Thus, Uroplakin II stands out as a reliable marker indicating urothelial lineage.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy