Which immunoprofile best fits colorectal carcinoma metastasis to the liver?

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Multiple Choice

Which immunoprofile best fits colorectal carcinoma metastasis to the liver?

Explanation:
Immunohistochemical patterns with CK7 and CK20 help identify the tissue of origin for metastatic adenocarcinomas. Colorectal carcinoma, reflecting intestinal differentiation, most often expresses CK20 and lacks CK7. When such cancer spreads to the liver, the metastatic cells typically retain this pattern: CK7 negative and CK20 positive. This makes the CK7−/CK20+ profile the best fit for colorectal metastasis. Other profiles point toward different primaries—for example, CK7 positive with CK20 negative is common in pancreaticobiliary and some gastric/gynecologic cancers, and CK7 positive with CK20 positive is less characteristic for colorectal metastases.

Immunohistochemical patterns with CK7 and CK20 help identify the tissue of origin for metastatic adenocarcinomas. Colorectal carcinoma, reflecting intestinal differentiation, most often expresses CK20 and lacks CK7. When such cancer spreads to the liver, the metastatic cells typically retain this pattern: CK7 negative and CK20 positive. This makes the CK7−/CK20+ profile the best fit for colorectal metastasis. Other profiles point toward different primaries—for example, CK7 positive with CK20 negative is common in pancreaticobiliary and some gastric/gynecologic cancers, and CK7 positive with CK20 positive is less characteristic for colorectal metastases.

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