Which IHCs would be positive for these lesional cells?

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Multiple Choice

Which IHCs would be positive for these lesional cells?

Explanation:
Neuroendocrine differentiation is identified by markers that label secretory granules in neuroendocrine cells. Synaptophysin and chromogranin are classic, widely used neuroendocrine markers, so their co-expression in lesional cells strongly supports a neuroendocrine tumor such as carcinoid or small cell carcinoma. The other marker pairs point to different lineages: p63/p40 indicate squamous cell lineage, TTF-1 and Napsin A point to pulmonary adenocarcinoma or thyroid origin, and HMB45 with Melan-A indicate melanocytic lesions. Thus, synaptophysin and chromogranin best fit a neuroendocrine profile for these cells.

Neuroendocrine differentiation is identified by markers that label secretory granules in neuroendocrine cells. Synaptophysin and chromogranin are classic, widely used neuroendocrine markers, so their co-expression in lesional cells strongly supports a neuroendocrine tumor such as carcinoid or small cell carcinoma.

The other marker pairs point to different lineages: p63/p40 indicate squamous cell lineage, TTF-1 and Napsin A point to pulmonary adenocarcinoma or thyroid origin, and HMB45 with Melan-A indicate melanocytic lesions. Thus, synaptophysin and chromogranin best fit a neuroendocrine profile for these cells.

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