Which IHC shows intense circumferential membranous staining?

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Multiple Choice

Which IHC shows intense circumferential membranous staining?

Explanation:
Intense circumferential membranous staining indicates a protein located on the cell surface. HER2 is a transmembrane receptor tyrosine kinase, so when overexpressed it presents as a strong, complete ring around each tumor cell on IHC. That membranous pattern distinguishes it from the others: ER and PR are nuclear receptors and show nuclear staining, while GATA3 is a nuclear transcription factor and also stains in the nucleus. So the membranous, circumferential pattern best fits HER2.

Intense circumferential membranous staining indicates a protein located on the cell surface. HER2 is a transmembrane receptor tyrosine kinase, so when overexpressed it presents as a strong, complete ring around each tumor cell on IHC. That membranous pattern distinguishes it from the others: ER and PR are nuclear receptors and show nuclear staining, while GATA3 is a nuclear transcription factor and also stains in the nucleus. So the membranous, circumferential pattern best fits HER2.

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