Which HPV types are responsible for >80% of Endocervical Adenocarcinomas?

• A. 16, 31, & 45
• B. 16, 18, & 31
• C. 18, 31, & 45
• D. 16, 18, & 45

Answer: (D)

Endocervical adenocarcinomas are strongly linked to HPV infection, with two types standing out as the most common drivers: HPV 16 and HPV 18. HPV 18 is particularly associated with glandular cancers in the cervix, while HPV 16 is also frequent. The next most commonly detected type in these tumors is HPV 45. When you consider all three together, they account for most HPV-positive endocervical adenocarcinomas—typically pushing the proportion above 80%. Other high-risk types like HPV 31 occur less often in this specific cancer type, so a set that includes 31 would not reach that same coverage. Thus, the combination of 16, 18, and 45 best explains the majority of endocervical adenocarcinomas.