Which HPV genotype trio is commonly associated with endocervical adenocarcinomas?

• A. 16, 31, & 45
• B. 16, 18, & 45
• C. 18, 31, & 45
• D. 16, 18, & 31

Answer: (B)

Endocervical adenocarcinoma is strongly linked to high‑risk HPV infections, with certain genotypes more commonly found in glandular cervical cancers. HPV 18 is particularly associated with adenocarcinomas, and HPV 45 also frequently appears in glandular lesions. HPV 16 is the most common genotype in cervical cancers overall and is seen frequently as well, contributing to endocervical adenocarcinomas alongside 18 and 45. By contrast, HPV 31 is more often tied to squamous lesions than to glandular cancers. So a trio that includes 16, 18, and 45 best reflects the genotypes commonly associated with endocervical adenocarcinoma.