Which breast cancer grouping is negative for estrogen receptor and HER2?

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Multiple Choice

Which breast cancer grouping is negative for estrogen receptor and HER2?

Explanation:
Receptor status-based grouping: Breast cancers are categorized by the presence or absence of estrogen receptor (ER), progesterone receptor (PR), and HER2. If a tumor lacks estrogen receptor and lacks HER2 expression, it fits triple-negative breast cancer, because it does not express ER or HER2 (and is commonly PR-negative as well). The other groups involve at least one of these receptors being expressed: luminal subtypes are ER-positive (and usually PR-positive) with HER2 negative or variable, while HER-2 Enriched is ER- and PR-negative but HER2-positive. So the combination ER-negative and HER2-negative points to triple-negative breast cancer.

Receptor status-based grouping: Breast cancers are categorized by the presence or absence of estrogen receptor (ER), progesterone receptor (PR), and HER2. If a tumor lacks estrogen receptor and lacks HER2 expression, it fits triple-negative breast cancer, because it does not express ER or HER2 (and is commonly PR-negative as well). The other groups involve at least one of these receptors being expressed: luminal subtypes are ER-positive (and usually PR-positive) with HER2 negative or variable, while HER-2 Enriched is ER- and PR-negative but HER2-positive. So the combination ER-negative and HER2-negative points to triple-negative breast cancer.

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