Which breast cancer grouping corresponds to estrogen receptor negative and HER2 positive status?

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Multiple Choice

Which breast cancer grouping corresponds to estrogen receptor negative and HER2 positive status?

Explanation:
The key idea is that breast cancers are categorized by receptor status: estrogen receptor (ER), progesterone receptor (PR), and HER2. When ER is negative and HER2 is positive, the tumor is classified as HER-2 Enriched. This group is driven by HER2 signaling rather than estrogen signaling, which is why therapies targeting HER2 (like trastuzumab) are effective. Luminal subtypes are ER positive, so they don’t fit ER-negative, and triple-negative lacks HER2 overexpression, so it isn’t HER-2 Enriched.

The key idea is that breast cancers are categorized by receptor status: estrogen receptor (ER), progesterone receptor (PR), and HER2. When ER is negative and HER2 is positive, the tumor is classified as HER-2 Enriched. This group is driven by HER2 signaling rather than estrogen signaling, which is why therapies targeting HER2 (like trastuzumab) are effective. Luminal subtypes are ER positive, so they don’t fit ER-negative, and triple-negative lacks HER2 overexpression, so it isn’t HER-2 Enriched.

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