Urovision detects aneuploidy in which chromosomes and loss of which locus?

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Multiple Choice

Urovision detects aneuploidy in which chromosomes and loss of which locus?

Explanation:
The test uses a FISH panel designed to detect common bladder cancer–associated chromosomal changes. It looks for extra copies (aneuploidy) of chromosomes 3, 7, and 17 in exfoliated urothelial cells, along with loss at the 9p21 locus. The 9p21 region includes the tumor suppressor gene CDKN2A/p16, so its deletion supports the presence of malignant cells. Alternatives that cite different chromosomes or a different locus don’t match the standard UroVysion probe set, which is specifically 3, 7, 17 for aneuploidy and 9p21 for locus loss.

The test uses a FISH panel designed to detect common bladder cancer–associated chromosomal changes. It looks for extra copies (aneuploidy) of chromosomes 3, 7, and 17 in exfoliated urothelial cells, along with loss at the 9p21 locus. The 9p21 region includes the tumor suppressor gene CDKN2A/p16, so its deletion supports the presence of malignant cells. Alternatives that cite different chromosomes or a different locus don’t match the standard UroVysion probe set, which is specifically 3, 7, 17 for aneuploidy and 9p21 for locus loss.

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