Luminal B breast cancer is typically positive for which marker combination?

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Multiple Choice

Luminal B breast cancer is typically positive for which marker combination?

Explanation:
Luminal B tumors are hormone receptor–positive but more aggressive than luminal A, often showing HER2 amplification or higher proliferation. The combination that best captures this biology is estrogen receptor–positive with HER2 positivity, which reflects the subset of luminal B cancers that are driven by both hormone signaling and HER2-driven growth. Choosing ER+ with HER2- would align more with luminal A, which tends to have lower proliferation and a better prognosis. ER-/HER2- cells are not luminal. So the marker pattern ER+ and HER2+ best fits the typical profile of luminal B.

Luminal B tumors are hormone receptor–positive but more aggressive than luminal A, often showing HER2 amplification or higher proliferation. The combination that best captures this biology is estrogen receptor–positive with HER2 positivity, which reflects the subset of luminal B cancers that are driven by both hormone signaling and HER2-driven growth.

Choosing ER+ with HER2- would align more with luminal A, which tends to have lower proliferation and a better prognosis. ER-/HER2- cells are not luminal. So the marker pattern ER+ and HER2+ best fits the typical profile of luminal B.

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