Loss of the 9p21 locus is detected by which test?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

Loss of the 9p21 locus is detected by which test?

Explanation:
Loss at the 9p21 region is a well-known deletion event because this area houses important tumor suppressor genes like CDKN2A (p16) and CDKN2B. Detecting this loss requires testing that specific locus, since you’re looking for whether that part of the chromosome is deleted. In practice, the test would target 9p21 with a probe or platform that assesses copy number at that region (for example, methods like FISH or array-based approaches). The other nearby 9q21, 9p13, or 9p12 regions are different loci and would not indicate loss of the 9p21 region. Therefore, the locus you test for loss is 9p21.

Loss at the 9p21 region is a well-known deletion event because this area houses important tumor suppressor genes like CDKN2A (p16) and CDKN2B. Detecting this loss requires testing that specific locus, since you’re looking for whether that part of the chromosome is deleted. In practice, the test would target 9p21 with a probe or platform that assesses copy number at that region (for example, methods like FISH or array-based approaches). The other nearby 9q21, 9p13, or 9p12 regions are different loci and would not indicate loss of the 9p21 region. Therefore, the locus you test for loss is 9p21.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy