In a high-grade carcinoma of the female genital tract, which immunohistochemical marker pair would you expect to be positive?

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Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

In a high-grade carcinoma of the female genital tract, which immunohistochemical marker pair would you expect to be positive?

High-grade neuroendocrine carcinomas of the female genital tract show neuroendocrine differentiation, which is best demonstrated by neuroendocrine markers such as CD56 and INSM1. INSM1 is a nuclear transcription factor that is highly sensitive and specific for neuroendocrine tumors, and CD56 (NCAM) is commonly expressed in these cancers. Their co-expression supports a neuroendocrine phenotype in a high-grade carcinoma. In contrast, CD79a and CD20 are B-cell markers; CK18 and EMA are general epithelial markers; S100 and HMB45 point to melanocytic lineage. Thus, the neuroendocrine marker pair is the most appropriate choice.

In a high-grade carcinoma of the female genital tract, which immunohistochemical marker pair would you expect to be positive?

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

In a high-grade carcinoma of the female genital tract, which immunohistochemical marker pair would you expect to be positive?

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