If a stain is positive for TTF-1 and PAX8, which staining result is described?

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Multiple Choice

If a stain is positive for TTF-1 and PAX8, which staining result is described?

Explanation:
TTF-1 and PAX8 positivity together points to thyroid origin. TTF-1 is expressed in thyroid and some lung epithelium, while PAX8 is expressed in thyroid and renal/urinary tract tissues. When both markers are positive, it strongly supports a thyroid-derived lesion rather than a primary lung tumor, which would usually show TTF-1 positivity without PAX8. The other patterns don’t fit this combined thyroid signature, so the described staining result is TTF-1, PAX8.

TTF-1 and PAX8 positivity together points to thyroid origin. TTF-1 is expressed in thyroid and some lung epithelium, while PAX8 is expressed in thyroid and renal/urinary tract tissues. When both markers are positive, it strongly supports a thyroid-derived lesion rather than a primary lung tumor, which would usually show TTF-1 positivity without PAX8. The other patterns don’t fit this combined thyroid signature, so the described staining result is TTF-1, PAX8.

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