Herceptin targets which receptor?

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Multiple Choice

Herceptin targets which receptor?

Explanation:
Herceptin targets the HER2 receptor. HER2 is a receptor tyrosine kinase that, when overexpressed, drives breast cancer growth. Trastuzumab binds to the extracellular part of HER2, blocking signaling by preventing receptor dimerization and promoting receptor downregulation. This reduces activity in pathways like PI3K/AKT and MAPK, slowing tumor cell growth and promoting immune-mediated destruction via antibody-dependent cellular cytotoxicity. The other markers listed are not the drug’s target: estrogen receptor and progesterone receptor indicate hormone-driven cancers and guide endocrine therapy, while GATA3 is a transcription factor, not a membrane receptor. Therefore, HER2 is the correct target.

Herceptin targets the HER2 receptor. HER2 is a receptor tyrosine kinase that, when overexpressed, drives breast cancer growth. Trastuzumab binds to the extracellular part of HER2, blocking signaling by preventing receptor dimerization and promoting receptor downregulation. This reduces activity in pathways like PI3K/AKT and MAPK, slowing tumor cell growth and promoting immune-mediated destruction via antibody-dependent cellular cytotoxicity. The other markers listed are not the drug’s target: estrogen receptor and progesterone receptor indicate hormone-driven cancers and guide endocrine therapy, while GATA3 is a transcription factor, not a membrane receptor. Therefore, HER2 is the correct target.

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