HER2/neu is encoded by which gene?

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Multiple Choice

HER2/neu is encoded by which gene?

Explanation:
HER2/neu is a protein that functions as a receptor tyrosine kinase in the epidermal growth factor receptor family. It is encoded by the ERBB2 gene. In many cancers, especially some breast cancers, ERBB2 can be amplified, leading to overexpression of HER2/neu, which has important implications for prognosis and treatment with targeted therapies like trastuzumab. The other genes listed encode different proteins: BAP1 is a tumor suppressor involved in mesothelioma risk, CDKN2A encodes cell cycle regulators p16 and related proteins, and BRCA1 is a breast/ovarian cancer susceptibility gene. None of these encode HER2/neu.

HER2/neu is a protein that functions as a receptor tyrosine kinase in the epidermal growth factor receptor family. It is encoded by the ERBB2 gene. In many cancers, especially some breast cancers, ERBB2 can be amplified, leading to overexpression of HER2/neu, which has important implications for prognosis and treatment with targeted therapies like trastuzumab. The other genes listed encode different proteins: BAP1 is a tumor suppressor involved in mesothelioma risk, CDKN2A encodes cell cycle regulators p16 and related proteins, and BRCA1 is a breast/ovarian cancer susceptibility gene. None of these encode HER2/neu.

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