HER2/neu is encoded by which gene?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

HER2/neu is encoded by which gene?

Explanation:
HER2/neu is the product of the ERBB2 gene. This gene encodes a receptor tyrosine kinase that sits on the cell surface and belongs to the epidermal growth factor receptor family. When ERBB2 is amplified, as seen in some breast cancers, HER2/neu is overexpressed, driving proliferative signaling and aggressive tumor behavior. That overexpression also makes tumors susceptible to targeted therapies like trastuzumab and other HER2-directed treatments. The other genes listed have different roles: BAP1 is a deubiquitinase linked to tumor suppression, CDKN2A encodes cell cycle regulators p16 and p14, and BRCA1 is involved in DNA repair.

HER2/neu is the product of the ERBB2 gene. This gene encodes a receptor tyrosine kinase that sits on the cell surface and belongs to the epidermal growth factor receptor family. When ERBB2 is amplified, as seen in some breast cancers, HER2/neu is overexpressed, driving proliferative signaling and aggressive tumor behavior. That overexpression also makes tumors susceptible to targeted therapies like trastuzumab and other HER2-directed treatments. The other genes listed have different roles: BAP1 is a deubiquitinase linked to tumor suppression, CDKN2A encodes cell cycle regulators p16 and p14, and BRCA1 is involved in DNA repair.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy