GIST stains positive for which markers?

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Multiple Choice

GIST stains positive for which markers?

Explanation:
GISTs are classically identified by markers of the interstitial cells of Cajal. The most supportive combination is c-KIT (CD117) and DOG-1, because most GISTs express KIT and DOG-1 is highly sensitive and specific for this tumor type, including in cases where KIT may be absent. Together, they provide strong confirmation of GIST. Other marker pairs point to different lineages—for example, CK7 and CDX2 are associated with epithelial/intestinal carcinomas, TTF-1 and PAX8 with lung/thyroid or renal/gynecologic tumors, and Melan-A with melanocytic lesions—so they do not fit GIST as well.

GISTs are classically identified by markers of the interstitial cells of Cajal. The most supportive combination is c-KIT (CD117) and DOG-1, because most GISTs express KIT and DOG-1 is highly sensitive and specific for this tumor type, including in cases where KIT may be absent. Together, they provide strong confirmation of GIST. Other marker pairs point to different lineages—for example, CK7 and CDX2 are associated with epithelial/intestinal carcinomas, TTF-1 and PAX8 with lung/thyroid or renal/gynecologic tumors, and Melan-A with melanocytic lesions—so they do not fit GIST as well.

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