Gastrointestinal stromal tumor (GIST) is typically confirmed by positivity for which two markers?

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Multiple Choice

Gastrointestinal stromal tumor (GIST) is typically confirmed by positivity for which two markers?

Explanation:
GISTs are diagnosed most reliably when the tumor cells express KIT (CD117) and DOG1. CD117 positivity reflects activating KIT mutations that drive protein overexpression in the majority of GISTs. DOG1, discovered on GIST-1, is highly sensitive and specific for GIST and can confirm the diagnosis even when CD117 is not as strong. Using both markers together provides the strongest evidence for GIST. The other marker patterns point to different tumor types (neural crest–derived, epithelial, or renal/Müllerian origin) and are not characteristic of GIST, so they don’t fit as well.

GISTs are diagnosed most reliably when the tumor cells express KIT (CD117) and DOG1. CD117 positivity reflects activating KIT mutations that drive protein overexpression in the majority of GISTs. DOG1, discovered on GIST-1, is highly sensitive and specific for GIST and can confirm the diagnosis even when CD117 is not as strong. Using both markers together provides the strongest evidence for GIST. The other marker patterns point to different tumor types (neural crest–derived, epithelial, or renal/Müllerian origin) and are not characteristic of GIST, so they don’t fit as well.

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