FOXL2 is a marker in which ovarian tumor IHC panel?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the CMID Test. Study with flashcards and multiple choice questions, each question contains hints and explanations. Get ready for your exam with confidence!

Multiple Choice

FOXL2 is a marker in which ovarian tumor IHC panel?

Explanation:
FOXL2 is a transcription factor expressed in granulosa cells, and a recurrent mutation (C134W) seen in adult-type granulosa cell tumors drives strong nuclear FOXL2 expression. Because of this, FOXL2 immunostaining is a highly useful marker to identify ovarian sex cord-stromal tumors, particularly granulosa cell tumors, and to distinguish them from other ovarian neoplasms and from non-ovarian tissues. Thus, FOXL2 is most informative for detecting primary ovarian sex cord tumors, not adrenal cortical tissue, parathyroid carcinoma, or other ovarian stromal sarcomas.

FOXL2 is a transcription factor expressed in granulosa cells, and a recurrent mutation (C134W) seen in adult-type granulosa cell tumors drives strong nuclear FOXL2 expression. Because of this, FOXL2 immunostaining is a highly useful marker to identify ovarian sex cord-stromal tumors, particularly granulosa cell tumors, and to distinguish them from other ovarian neoplasms and from non-ovarian tissues. Thus, FOXL2 is most informative for detecting primary ovarian sex cord tumors, not adrenal cortical tissue, parathyroid carcinoma, or other ovarian stromal sarcomas.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy