EGFR mutations in lung carcinomas are associated with which histology?

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Multiple Choice

EGFR mutations in lung carcinomas are associated with which histology?

Explanation:
EGFR mutations act as driver changes in a subset of lung cancers, and they are most commonly found in the adenocarcinoma histology. Adenocarcinoma typically arises peripherally in the lung and is more common in non-smokers or light smokers, women, and certain populations, making activating EGFR mutations a frequent feature. These mutations cause the EGFR tyrosine kinase to stay active, which is why tumors with them respond well to EGFR inhibitors. Other histologies—squamous cell, small cell, and large cell carcinomas—are less likely to harbor activating EGFR mutations and are driven by different molecular patterns.

EGFR mutations act as driver changes in a subset of lung cancers, and they are most commonly found in the adenocarcinoma histology. Adenocarcinoma typically arises peripherally in the lung and is more common in non-smokers or light smokers, women, and certain populations, making activating EGFR mutations a frequent feature. These mutations cause the EGFR tyrosine kinase to stay active, which is why tumors with them respond well to EGFR inhibitors. Other histologies—squamous cell, small cell, and large cell carcinomas—are less likely to harbor activating EGFR mutations and are driven by different molecular patterns.

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