Clinical staging is established before initiation of therapy.

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Multiple Choice

Clinical staging is established before initiation of therapy.

Explanation:
Clinical staging is established before starting therapy to guide treatment decisions and prognosis. It uses exam, imaging, and biopsy to determine tumor size, nodal involvement, and metastasis, giving the clinical stage (cTNM). Pathological staging (pTNM) is determined after tissue is examined and can refine the stage. In many situations, patients may receive neoadjuvant therapy before surgery, but the initial clinical stage formed at presentation still drives the chosen treatment approach, with restaging after therapy providing updated information. So the statement is true.

Clinical staging is established before starting therapy to guide treatment decisions and prognosis. It uses exam, imaging, and biopsy to determine tumor size, nodal involvement, and metastasis, giving the clinical stage (cTNM). Pathological staging (pTNM) is determined after tissue is examined and can refine the stage. In many situations, patients may receive neoadjuvant therapy before surgery, but the initial clinical stage formed at presentation still drives the chosen treatment approach, with restaging after therapy providing updated information. So the statement is true.

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