CK7 (-), CK20 (+) favors which systems?

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Multiple Choice

CK7 (-), CK20 (+) favors which systems?

Explanation:
CK7 negative and CK20 positive is a pattern that points toward tumors from the GI tract, especially colorectal cancer, and to Merkel cell carcinoma of the skin. CK7 is commonly found in many organs like lung, breast, and gynecologic tissues, where CK20 is not usually present. In contrast, CK20 is characteristic of colorectal epithelium and Merkel cell carcinoma, which typically shows CK7 negativity. So this immunoprofile helps distinguish these origins from other sites such as lung, breast, or uterus/ovary, which usually show CK7 positivity. The combination of CK7-/CK20+ therefore best fits the GI tract (colorectal) and Merkel cell origins.

CK7 negative and CK20 positive is a pattern that points toward tumors from the GI tract, especially colorectal cancer, and to Merkel cell carcinoma of the skin. CK7 is commonly found in many organs like lung, breast, and gynecologic tissues, where CK20 is not usually present. In contrast, CK20 is characteristic of colorectal epithelium and Merkel cell carcinoma, which typically shows CK7 negativity. So this immunoprofile helps distinguish these origins from other sites such as lung, breast, or uterus/ovary, which usually show CK7 positivity. The combination of CK7-/CK20+ therefore best fits the GI tract (colorectal) and Merkel cell origins.

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