____ are EGFR TK Inhibitors (TKI)

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Multiple Choice

____ are EGFR TK Inhibitors (TKI)

Explanation:
EGFR tyrosine kinase inhibitors are small molecules that block the intracellular kinase activity of EGFR, preventing autophosphorylation and shut down of downstream signaling that promotes cancer cell growth. Gefitinib and erlotinib are classic examples of this class, directly inhibiting EGFR’s kinase domain. Herceptin, by contrast, is a monoclonal antibody that targets HER2 and is not a tyrosine kinase inhibitor, so it doesn’t belong to the EGFR TKI group. Therefore, erlotinib and gefitinib are the ones that fit as EGFR TK inhibitors.

EGFR tyrosine kinase inhibitors are small molecules that block the intracellular kinase activity of EGFR, preventing autophosphorylation and shut down of downstream signaling that promotes cancer cell growth. Gefitinib and erlotinib are classic examples of this class, directly inhibiting EGFR’s kinase domain. Herceptin, by contrast, is a monoclonal antibody that targets HER2 and is not a tyrosine kinase inhibitor, so it doesn’t belong to the EGFR TKI group. Therefore, erlotinib and gefitinib are the ones that fit as EGFR TK inhibitors.

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